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dc.contributor.advisorPosada Buitrago, Martha Lucía
dc.contributor.authorRomero Ariza, Laura Milena
dc.contributor.authorRamírez Tovar, Geraldine
dc.date.accessioned2021-06-18T20:52:44Z
dc.date.available2021-06-18T20:52:44Z
dc.date.issued2020-11-13
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/263
dc.description.abstractLos microorganismos endófitos se encuentran en los espacios intercelulares de las plantas sin generar daño alguno, es así como se presenta una asociación mutualista endófito- planta, donde la planta brinda nutrición y hospedaje al endófito y a cambio ésta recibe beneficios para su supervivencia, lo anterior gracias a que los endófitos poseen la capacidad de producir metabolitos secundarios que le confieren a la planta diversas propiedades. Además, existen estudios que demuestran que estos metabolitos también tienen aplicaciones en el ámbito de la medicina. El género Vaccinium está compuesto por diferentes especies entre las cuales se encuentran V. angustifolium, V. corymbosum y V. myrtillus, que son conocidas como arándanos y se distribuyen a nivel mundial; en Latinoamérica se encuentra la especie V. meridionale y es llamada comúnmente ‘‘mortiño’’. Estas plantas se destacan por producir metabolitos secundarios que le confieren propiedades antioxidantes y antimicrobianas, así mismo características medicinales, ya que actúan como antidiabéticos y antitumorales. Estos metabolitos también pueden ser producidos o estimulados por las comunidades endófitas presentes en las plantas, por lo cual son una gran alternativa para el desarrollo de nuevos medicamentos o cuidados paliativos para enfermedades que suelen presentar complicaciones o reacciones secundarias a los tratamientos comunes. En la presente revisión se profundizó en los diferentes microorganismos endófitos descritos en el género Vaccinium, así como los metabolitos secundarios producidos por los mismos, donde se pudo establecer que los metabolitos secundarios de los endófitos como son candidatos potenciales para el tratamiento de diferentes enfermedades por medio del desarrollo de nuevos medicamentos.spa
dc.description.abstractEndophytic microorganisms are found in the intercellular spaces of plants without causing any damage, this is how an endophyte-plant mutualistic association occurs, where the plant provides nutrition and harbors the endophyte and in return it receives benefits for its survival, the above thanks because endophytes have the ability to produce secondary metabolites that confer various properties to the plant. In addition, there are studies that show that these metabolites also have applications in the field of medicine. The genus Vaccinium is made up of different species, including V. angustifolium, V. corymbosum and V. myrtillus, which are known as blueberries and are distributed worldwide; the species V. meridionale is present only in Latin America and it is known as "mortiño". These plants stand out for producing secondary metabolites that confer antioxidant and antimicrobial properties, as well as other medicinal characteristics, since they act as antidiabetic and antitumor agents. These metabolites can also be produced or stimulated by endophytic communities present in plants, which is why they are a great alternative for the development of new drugs or palliative care for diseases that usually present complications or secondary reactions to common treatments. In the present review, the different endophytic microorganisms described in the Vaccinium genus were studied in depth, as well as the secondary metabolites produced by them, where it was established that endophyte secondary metabolites are potential candidates for the treatment of different diseases by means of the development of new drugs.eng
dc.description.tableofcontents1. Introducción 12 2. Objetivos 15 2.1 Objetivo general 2.2 Objetivos específicos 3. Antecedentes 16 4. Marco teórico 24 4.1 Endófitos 24 4.2 Metabolitos secundarios 28 4.3 Género Vaccinium 35 4.3.1 Mortiño 35 4.3.2 Arandano 38 4.4 Actividad antioxidante 40 4.4.1 Radicales libres 41 4.4.2 Antioxidantes 42 4.4.2.1 Polifenoles 42 4.4.2.1.1 Flavonoides 43 4.4.2.1.2 Proantocianidinas (Taninos condensados) 44 4.4.2.1.3 Antocianinas 45 4.4.2.2 Acido ascorbico (VitaminaC) 46 4.5 Microorganismos endófitos presentes en el género Vaccinium como fuentede fármacos 46 4.6 Microorganismos endófitos y actividad antioxidante 49 5. Diseño metodológico 51 5.1 Tipo de investigación 51 5.2 Universo 51 5.3 Población 51 5.4 Muestra 51 5.5 Métodos 52 5.5.1 Revisión de información existente 52 5.5.2 Selección del material bibliográfico de acuerdo a la temática a tratar 52 5.5.3 Estructuración coherente del documento 53 6. Resultados 53 6.1 Fase 1. Búsqueda y revisión de la información 53 6.2 Fase 2. Selección del material bibliográfico 57 6.3 Fase 3. Organización lógica del documento 58 6.4 Fase 4. Analisis de la información 58 7. Discusión 63 8. Conclusiones 69 9. Recomendaciones 70 10. Bibliografía 71 Anexosspa
dc.format.extent102p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2020spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleMicroorganismos endófitos presentes en las especies vegetales del género vaccinium como productores de metabolitos secundarios con potencial farmacológico.spa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembEspecies vegetales
dc.subject.lembFarmacología
dc.subject.lembArándanos
dc.subject.proposalMicroorganismos endófitosspa
dc.subject.proposalVacciniumspa
dc.subject.proposalMetabolitos secundariosspa
dc.subject.proposalEnfermedadspa
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dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
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