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Determinación de proteínas Neuromoduladoras TIMP-2 y sgp130 en plasma de sangre de cordón Umbilical en Neonatos Colombianos y su correlación con variables materno fetales.
dc.contributor.advisor | Cruz Baquero, Claudia Andrea | |
dc.contributor.advisor | Avila Portillo, Luz Mabel | |
dc.contributor.author | Holguín Rincón, Lizeth Daniela | |
dc.contributor.author | Lemus López, Katherin Julieth | |
dc.contributor.author | Tovar Suárez, César Andrés | |
dc.date.accessioned | 2021-09-09T20:38:26Z | |
dc.date.available | 2021-09-09T20:38:26Z | |
dc.date.issued | 2021-04-30 | |
dc.identifier.uri | https://repositorio.unicolmayor.edu.co/handle/unicolmayor/2833 | |
dc.description.abstract | La sangre de cordón umbilical (SCU), es considerada sangre fetal y emerge por sus propiedades como un componente biológico con potencial terapéutico en diferentes entidades. En el plasma de sangre de cordón umbilical (PSCU) se encuentran proteínas relacionadas con la angiogénesis, quimiocinas, factores de crecimiento y moléculas relacionadas con la matriz extracelular entre otras, dentro de las proteínas con mayor concentración están la proteína inhibidora de las metaloproteinasas (TIMP-2) y la glicoproteína 130 soluble (sgp130), las cuales están asociadas a neurogénesis y revitalización del hipocampo en ratones viejos. Este trabajo tiene como objetivo determinar las concentraciones de las proteínas neuromoduladoras TIMP-2 y sgp130 presentes en PSCU. Fue aprobado por el comité de Ética en Investigación del Hospital Militar Central y realizado en los laboratorios de STEM Medicina Regenerativa, previa firma del consentimiento informado de las maternas se obtuvo y procesó el PSCU de 121 neonatos para la cuantificación de TIMP-2 y sgp130 mediante la técnica ELISA. El valor promedio de TIMP-2 fue de 100,1 pg/ml (rango de 1,9 a 485,7 pg/ml) con (SD) de 105,4, el valor promedio de sgp130 fue de 641,1 pg/ml (rango de 0 a 1595, 7 pg/ml) con una (SD) de 295. No existió correlación del valor de las proteínas con peso, talla, células nucleadas totales (CN), recuento de CD34+ y semanas de gestación. Este trabajo apropia conocimiento de los valores de TIMP2 y sgp30 en PSCU, los cuales deben ser considerados para estudios de medicina traslacional. | spa |
dc.description.tableofcontents | RESUMEN 1. INTRODUCCIÓN 16 2. OBJETIVOS 18 2.1 Objetivo general 18 2.2 Objetivos específicos 18 3. ANTECEDENTES 19 4. MARCO TEÓRICO 32 4.1 Fisiología y anatomía del cordón umbilical 32 4.2 Sangre de cordón umbilical 33 4.3 Plasma de cordón umbilical 35 4.4 Fisiología y anatomía del hipocampo 36 4.5 Enfermedades neurodegenerativas 37 4.6 Alzheimer 38 4.6.1 Fisiopatología 38 4.6.2 Alteraciones genéticas 40 4.6.3 Consecuencias 40 4.7 Generalidades y funciones de los inhibidores de las metaloproteinasas 41 4.8 TIMP-2 41 4.8.1 Estudios en animales 41 4.8.2 Estudios en humanos 43 4.9 IL-6 44 4.10 Generalidades y funciones de la glicoproteína 130 45 4.11 Glicoproteína 130 soluble 46 4.11.1 Utilidades a nivel neuronal 46 4.12 Ensayo inmunoabsorbente ligado a enzimas 47 5 MATERIALES Y MÉTODOS 49 5.1 Clasificación del diseño de investigación y alcance de la investigación 49 5.2 Población 49 5.3 Selección y tamaño de la muestra 51 5.4 Criterios de inclusión y exclusión 52 5.5 Variables 52 5.5.1 Variables dependientes 52 5.5.2 Variables independientes 52 5.5.3 Definiciones de variables 53 5.6 Obtención y procesamiento de muestras 54 5.7 Determinación de TIMP-2 55 5.8 Determinación de sgp130 56 6. PLAN DE ANÁLISIS 57 6.1 Análisis de datos 57 6.2 Análisis estadístico 57 7. RESULTADOS 58 8. DISCUSIÓN 71 9. CONCLUSIONES 79 10. ASPECTO ÉTICOS 80 REFERENCIAS 82 ANEXOS | spa |
dc.format.extent | 104p. | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.publisher | Universidad Colegio Mayor de Cundinamarca | spa |
dc.rights | Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2021 | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | spa |
dc.title | Determinación de proteínas Neuromoduladoras TIMP-2 y sgp130 en plasma de sangre de cordón Umbilical en Neonatos Colombianos y su correlación con variables materno fetales. | spa |
dc.type | Trabajo de grado - Pregrado | spa |
dc.description.degreelevel | Pregrado | spa |
dc.description.degreename | Bacteriólogo(a) y Laboratorista Clínico | spa |
dc.publisher.faculty | Facultad de Ciencias de la Salud | spa |
dc.publisher.place | Bogotá D.C | spa |
dc.publisher.program | Bacteriología y Laboratorio Clínico | spa |
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dc.rights.accessrights | info:eu-repo/semantics/closedAccess | spa |
dc.rights.creativecommons | Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) | spa |
dc.subject.lemb | Proteínas Neuromoduladoras | |
dc.subject.lemb | Neonatos | |
dc.subject.lemb | Plasma | |
dc.subject.lemb | Angiogénesis | |
dc.subject.proposal | TIMP-2 | spa |
dc.subject.proposal | sgp130 | spa |
dc.subject.proposal | Hipocampo | spa |
dc.subject.proposal | Plasma de sangre de cordón umbilical | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_7a1f | spa |
dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.type.content | Text | spa |
dc.type.driver | info:eu-repo/semantics/bachelorThesis | spa |
dc.type.redcol | https://purl.org/redcol/resource_type/TP | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.rights.coar | http://purl.org/coar/access_right/c_14cb | spa |