Mostrar el registro sencillo del ítem

Determinación de proteínas Neuromoduladoras TIMP-2 y sgp130 en plasma de sangre de cordón Umbilical en Neonatos Colombianos y su correlación con variables materno fetales.

dc.contributor.advisorCruz Baquero, Claudia Andrea
dc.contributor.advisorAvila Portillo, Luz Mabel
dc.contributor.authorHolguín Rincón, Lizeth Daniela
dc.contributor.authorLemus López, Katherin Julieth
dc.contributor.authorTovar Suárez, César Andrés
dc.date.accessioned2021-09-09T20:38:26Z
dc.date.available2021-09-09T20:38:26Z
dc.date.issued2021-04-30
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/2833
dc.description.abstractLa sangre de cordón umbilical (SCU), es considerada sangre fetal y emerge por sus propiedades como un componente biológico con potencial terapéutico en diferentes entidades. En el plasma de sangre de cordón umbilical (PSCU) se encuentran proteínas relacionadas con la angiogénesis, quimiocinas, factores de crecimiento y moléculas relacionadas con la matriz extracelular entre otras, dentro de las proteínas con mayor concentración están la proteína inhibidora de las metaloproteinasas (TIMP-2) y la glicoproteína 130 soluble (sgp130), las cuales están asociadas a neurogénesis y revitalización del hipocampo en ratones viejos. Este trabajo tiene como objetivo determinar las concentraciones de las proteínas neuromoduladoras TIMP-2 y sgp130 presentes en PSCU. Fue aprobado por el comité de Ética en Investigación del Hospital Militar Central y realizado en los laboratorios de STEM Medicina Regenerativa, previa firma del consentimiento informado de las maternas se obtuvo y procesó el PSCU de 121 neonatos para la cuantificación de TIMP-2 y sgp130 mediante la técnica ELISA. El valor promedio de TIMP-2 fue de 100,1 pg/ml (rango de 1,9 a 485,7 pg/ml) con (SD) de 105,4, el valor promedio de sgp130 fue de 641,1 pg/ml (rango de 0 a 1595, 7 pg/ml) con una (SD) de 295. No existió correlación del valor de las proteínas con peso, talla, células nucleadas totales (CN), recuento de CD34+ y semanas de gestación. Este trabajo apropia conocimiento de los valores de TIMP2 y sgp30 en PSCU, los cuales deben ser considerados para estudios de medicina traslacional.spa
dc.description.tableofcontentsRESUMEN 1. INTRODUCCIÓN 16 2. OBJETIVOS 18 2.1 Objetivo general 18 2.2 Objetivos específicos 18 3. ANTECEDENTES 19 4. MARCO TEÓRICO 32 4.1 Fisiología y anatomía del cordón umbilical 32 4.2 Sangre de cordón umbilical 33 4.3 Plasma de cordón umbilical 35 4.4 Fisiología y anatomía del hipocampo 36 4.5 Enfermedades neurodegenerativas 37 4.6 Alzheimer 38 4.6.1 Fisiopatología 38 4.6.2 Alteraciones genéticas 40 4.6.3 Consecuencias 40 4.7 Generalidades y funciones de los inhibidores de las metaloproteinasas 41 4.8 TIMP-2 41 4.8.1 Estudios en animales 41 4.8.2 Estudios en humanos 43 4.9 IL-6 44 4.10 Generalidades y funciones de la glicoproteína 130 45 4.11 Glicoproteína 130 soluble 46 4.11.1 Utilidades a nivel neuronal 46 4.12 Ensayo inmunoabsorbente ligado a enzimas 47 5 MATERIALES Y MÉTODOS 49 5.1 Clasificación del diseño de investigación y alcance de la investigación 49 5.2 Población 49 5.3 Selección y tamaño de la muestra 51 5.4 Criterios de inclusión y exclusión 52 5.5 Variables 52 5.5.1 Variables dependientes 52 5.5.2 Variables independientes 52 5.5.3 Definiciones de variables 53 5.6 Obtención y procesamiento de muestras 54 5.7 Determinación de TIMP-2 55 5.8 Determinación de sgp130 56 6. PLAN DE ANÁLISIS 57 6.1 Análisis de datos 57 6.2 Análisis estadístico 57 7. RESULTADOS 58 8. DISCUSIÓN 71 9. CONCLUSIONES 79 10. ASPECTO ÉTICOS 80 REFERENCIAS 82 ANEXOSspa
dc.format.extent104p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2021spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleDeterminación de proteínas Neuromoduladoras TIMP-2 y sgp130 en plasma de sangre de cordón Umbilical en Neonatos Colombianos y su correlación con variables materno fetales.spa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
dc.relation.referencesAlzheimer Disease International. Informe Mundial sobre el Alzheimer 2019 Actitudes hacia la demencia. Glob voice Dement [Internet]. 2019;13. Available from: https://www.alz.co.uk/research/WorldAlzheimerReport2019-Spanish-Summary.pdfspa
dc.relation.referencesRuiz C, Nariño D, Muñoz J. Epidemiología de la Enfermedad de Alzheimer. Rev Neuropsiquiatr [Internet]. 2013;58(3):180–3. Available from: https://www.acnweb.org/acta/acta_2010_26_Supl3_1_87-94.pdfspa
dc.relation.referencesCastellano JM, Mosher KI, Abbey RJ, Mcbride AA, James ML, Berdnik D, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature [Internet]. 2017;544(7651):488–92. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586222/spa
dc.relation.referencesHarper E. Collagenases. Ann Rev Biochem [Internet]. 1980;49:1063–78. Available from: https://www.annualreviews.org/doi/abs/10.1146/annurev.bi.49.070180.005215?journal Code=biochem %0Aspa
dc.relation.referencesCawston TE, Galloway WA, Mercer E, Murphy G, Reynolds JJ. Purification of rabbit bone inhibitor of collagenase. Biochem J [Internet]. 1981;195(1):159–65. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1162866/pdf/biochemj00402- 0164.pdfspa
dc.relation.referencesOkada Y, Nagase H, Harris E. Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints. J Rheumatol [Internet]. 1987;14:41–2. Available from: https://pubmed.ncbi.nlm.nih.gov/3305938/ %09spa
dc.relation.referencesStetler-Stevenson WG, Krutzsch HC, Liotta LA. Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem [Internet]. 1989;264(29):17374–8. Available from: http://dx.doi.org/10.1016/S0021- 9258(18)71503-2spa
dc.relation.referencesLambert E, Dassé E, Haye B, Petitfrère E. TIMPs as multifacial proteins. Crit Rev Oncol Hematol [Internet]. 2004;49(3):187–98. Available from: https://www.sciencedirect.com/science/article/pii/S1040842803002749spa
dc.relation.referencesPérez-Martínez L, Jaworski DM. Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal. J Neurosci [Internet]. 2005;25(20):4917–29. Available from: https://www.jneurosci.org/content/25/20/4917.fullspa
dc.relation.referencesBrew K. Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases. FASEB J. 2019;33(1):71–87.spa
dc.relation.referencesCardenas V, Guevara L. Cuantificación de TIMP-2 en plasmas de sangre de cordón umbilical de neonatos colombianos y su correlación con variables neonatales utilizando el método CBA en citometría de flujo. Universidad Colegio Mayor de Cundinamarca; 2019.spa
dc.relation.referencesTaga T. gp130, A shared signal transducing receptor component for hematopoietic and neuropoietic cytokines. J Neurochem [Internet]. 1996;67(1):1–10. Available from: https://www.ncbi.nlm.nih.gov/pubmed/8666978spa
dc.relation.referencesJostock T, Müllberg J, Özbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem [Internet]. 2001;268(1):160–7. Available from: https://febs.onlinelibrary.wiley.com/doi/full/10.1046/j.1432- 1327.2001.01867.x?sid=nlm%3Apubmedspa
dc.relation.referencesAugustyniak D, Majkowska-Skrobek G, Basiewicz-Worsztynowicz B, Jankowski A. The role of IL-6/sIL-6R complex and its natural inhibitor sgp130 in modulation of inflammatory process. Postepy Biochem [Internet]. 2006;52(2):194–203. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17078509 %0Aspa
dc.relation.referencesErta M, Quintana A, Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci [Internet]. 2012;8(9):1254–66. Available from: https://www.ijbs.com/v08p1254.htmspa
dc.relation.referencesRothaug M, Becker-Pauly C, Rose-John S. The role of interleukin-6 signaling in nervous tissue. Biochim Biophys Acta - Mol Cell Res [Internet]. 2016;1863(6):1218– 27. Available from: http://dx.doi.org/10.1016/j.bbamcr.2016.03.018spa
dc.relation.referencesEscrig A, Canal C, Sanchis P, Fernández-Gayol O, Montilla A, Comes G, et al. IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease. Brain Behav Immun [Internet]. 2019;82:145–59. Available from: https://doi.org/10.1016/j.bbi.2019.08.005spa
dc.relation.referencesStrelau J, Sullivan A, Bottner M, Lingor P, Falkenstein E, Suter-Crazzolara C, et al. Growth/differentiation factor-15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. J Neurosci [Internet]. 2000;20(23):8597–603. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773071/spa
dc.relation.referencesSanchez-Ramos JR, Song S, Kamath SG, Zigova T, Willing A, Cardozo-Pelaez F, et al. Expression of neural markers in human umbilical cord blood. Exp Neurol [Internet]. 2001;171(1):109–15. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0014488601977489?via%3Dih ubspa
dc.relation.referencesEhrhart J, Sanberg PR, Garbuzova-Davis S. Plasma derived from human umbilical cord blood: Potential cell-additive or cell-substitute therapeutic for neurodegenerative diseases. J Cell Mol Med [Internet]. 2018;22(12):6157–66. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237605spa
dc.relation.referencesKim DH, Lee D, Lim H, Choi SJ, Oh W, Yang YS, et al. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer’s disease. Biochem Biophys Res Commun [Internet]. 2018;504(4):933–40. Available from: https://doi.org/10.1016/j.bbrc.2018.09.012spa
dc.relation.referencesHuang YJ, Lee CY, Cao J, Lee HS, Chang CH, Chen P Da, et al. Therapeutic Potential of Plasma Proteins Derived from Umbilical Cord Blood for Acute Liver Failure. Mol Pharm [Internet]. 2019;16(3):1092–104. Available from: https://pubmed.ncbi.nlm.nih.gov/30698974/spa
dc.relation.referencesBae SH, Jo A, Park JH, Lim CW, Choi Y, Oh J, et al. Bioassay for monitoring the anti- aging effect of cord blood treatment. Theranostics [Internet]. 2019;9(1):1–10. Available from: doi:10.7150/thno.30422spa
dc.relation.referencesKheifets V, Braithwaite SP. Plasma-Based Strategies for Therapeutic Modulation of Brain Aging. Neurotherapeutics [Internet]. 2019;16(3):675–84. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694331/spa
dc.relation.referencesCastellano JM. Blood-Based Therapies to Combat Aging. Gerontology [Internet]. 2019;65(1):84–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335155/spa
dc.relation.referencesHo L, Fukuchi KI, Younkin SG. The alternatively spliced Kunitz protease inhibitor domain alters amyloid β protein precursor processing and amyloid β protein production in cultured cells. J Biol Chem [Internet]. 1996;271(48):30929–34. Available from: http://dx.doi.org/10.1074/jbc.271.48.30929spa
dc.relation.referencesGeorge-Hyslop PHS. Alzheimer ’ s. Sci Am [Internet]. 2000;283(6):76–83. Available from: https://sites.oxy.edu/clint/physio/article/alzheimers.pdfspa
dc.relation.referencesHashimoto M, Rockenstein E, Crews L, Masliah E. Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer’s and Parkinson’s Diseases. NeuroMolecular Med [Internet]. 2003;4(1–2):21–35. Available from: https://pubmed.ncbi.nlm.nih.gov/14528050/spa
dc.relation.referencesPriller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J. Synapse formation and function is modulated by the amyloid precursor protein. J Neurosci [Internet]. 2006;26(27):7212–21. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16822978spa
dc.relation.referencesBurke SN, Barnes CA. Neural plasticity in the ageing brain. Nat Rev Neurosci [Internet]. 2006;7(1):30–40. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16371948spa
dc.relation.referencesKhan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, et al. Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer’s disease. Nat Neurosci [Internet]. 2014;17(2):304–11. Available from: https://www.nature.com/articles/nn.3606spa
dc.relation.referencesJiao SS, Yao XQ, Liu YH, Wang QH, Zeng F, Lu JJ, et al. Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits. Proc Natl Acad Sci U S A [Internet]. 2015;112(16):5225–30. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25847999spa
dc.relation.referencesCroese T, Furlan R. Extracellular vesicles in neurodegenerative diseases. Mol Aspects Med [Internet]. 2018;60:52–61. Available from: https://doi.org/10.1016/j.mam.2017.11.006spa
dc.relation.referencesToda T, Parylak SL, Linker SB, Gage FH. The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry [Internet]. 2019;24(1):67–87. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16822978spa
dc.relation.referencesKim DW, Staples M, Shinozuka K, Pantcheva P, Kang SD, Borlongan C V. Wharton’s jelly-derived mesenchymal stem cells: Phenotypic characterization and Optimizing their therapeutic potential for clinical applications. Int J Mol Sci [Internet]. 2013;14(6):11692–712. Available from: https://www.mdpi.com/1422- 0067/14/6/11692spa
dc.relation.referencesMottet N, Chaussy Y, Arbez-Gindre F, Riethmuller D. Fisiología y patologías del cordón umbilical. EMC - Ginecol [Internet]. 2017 [cited 2021 Feb 24];53(4):1–12. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1283081X17868879spa
dc.relation.referencesMontalvo A. Tisular, Evaluación genética y microanalítica de las células madre de la gelatina de wharton para su utilización en ingeniería [Internet]. Universidad de Granada; 2008. Available from: https://hera.ugr.es/tesisugr/1768058x.pdfspa
dc.relation.referencesMuratore CS, Wilson JM. ARTIFICIAL WOMB. In: Principles of Tissue Engineering [Internet]. Elsevier; 2000 [cited 2021 Feb 24]. p. 905–12. Available from: https://www.sciencedirect.com/science/article/pii/B9780124366305500684?via%3Dih ub %0Aspa
dc.relation.referencesCord U, Banking B. ACOG Committee Opinion #297. Obstet Gynecol [Internet]. 2004;104(2):423–4. Available from: https://pubmed.ncbi.nlm.nih.gov/30801478/spa
dc.relation.referencesLiao Y, Geyer MB, Yang AJ, Cairo MS. Cord blood transplantation and stem cell regenerative potential. Exp Hematol [Internet]. 2011;39(4):393–412. Available from: http://dx.doi.org/10.1016/j.exphem.2011.01.002spa
dc.relation.referencesNewcomb JD, Sanberg PR, Klasko SK, Willing AE. Umbilical cord blood research: Current and future perspectives. Cell Transplant [Internet]. 2007;16(2):151–8. Available from: https://pubmed.ncbi.nlm.nih.gov/17474296/.spa
dc.relation.referencesKnierim JJ. The hippocampus. Curr Biol [Internet]. 2015;25(23):R1116–21. Available from: https://doi.org/10.1016/j.cub.2015.10.049spa
dc.relation.referencesJohn O. Hippocampal Neurophysiology in the Behaving Animal. Hippocampus B. 2009;spa
dc.relation.referencesAguirre Siancas EE. Hippocampal function in memory processing and its deterioration in aging. Rev Mex Neurocienc [Internet]. 2016;16(4):21–30. Available from: http://www.medigraphic.com/cgi bin/new/resumen.cgi?IDARTICULO=64941spa
dc.relation.referencesSchultz C, Engelhardt M. Anatomy of the hippocampal formation. Hippocampus Clin Neurosci [Internet]. 2014;34:6–17. Available from: https://pubmed.ncbi.nlm.nih.gov/24777126/spa
dc.relation.referencesDugger BN, Dickson DW. Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol [Internet]. 2017;9(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495060/spa
dc.relation.referencesDickson DW. Neuropathology of non-Alzheimer degenerative disorders. Int J Clin Exp Pathol [Internet]. 2010;3(1):1–23. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495060/%0Aspa
dc.relation.referencesRekatsina M, Paladini A, Piroli A, Zis P, Pergolizzi J V., Varrassi G. Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review. Adv Ther [Internet]. 2020;37(1):113–39. Available from: https://doi.org/10.1007/s12325-019-01148-5spa
dc.relation.referencesMann DMA. The pathological association between down syndrome and Alzheimer disease. Mech Ageing Dev [Internet]. 1988;43(2):99–136. Available from: https://www.sciencedirect.com/science/article/abs/pii/0047637488900413 %0Aspa
dc.relation.referencesXia E, Xu F, Hu C, Kumal JPP, Tang X, Mao D, et al. Young Blood Rescues the Cognition of Alzheimer’s Model Mice by Restoring the Hippocampal Cholinergic Circuit. Neuroscience [Internet]. 2019;417:57–69. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(19)30552-4spa
dc.relation.referencesTuna G, Yener GG, Oktay G, Işlekel GH, Kirkali FG. Evaluation of Matrix Metalloproteinase-2 (MMP-2) and-9 (MMP-9) and Their Tissue Inhibitors (TIMP-1 and TIMP-2) in Plasma from Patients with Neurodegenerative Dementia. J Alzheimer’s Dis [Internet]. 2018;66(3):1265–73. Available from: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180752spa
dc.relation.referencesLorenzl S, Albers DS, Relkin N, Ngyuen T, Hilgenberg SL, Chirichigno J, et al. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease. Neurochem Int [Internet]. 2003;43(3):191–6. Available from: https://sci- hub.tw/https://doi.org/10.1016/S0197-0186(03)00004-4spa
dc.relation.referencesMichalopoulou M, Nikolaou C, Tavernarakis A, Alexandri NM, Rentzos M, Chatzipanagiotou S, et al. Soluble interleukin-6 receptor (sIL-6R) in cerebrospinal fluid of patients with inflammatory and non inflammatory neurological diseases. Immunol Lett [Internet]. 2004;94(3):183–9. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0165247804001130%0Aspa
dc.relation.referencesRamos dos Santos L, Belcavello L, Camporez D, Iamonde Maciel de Magalhães C, Zandonade E, Lírio Morelato R, et al. Association study of the BIN1 and IL-6 genes on Alzheimer’s disease. Neurosci Lett [Internet]. 2016;614:65–9. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0304394015303372?via%3Dih ub %0Aspa
dc.relation.referencesMcKusick V, Kniffin C. INTERLEUKIN 6 SIGNAL TRANSDUCER; IL6ST [Internet]. OMIN. 1995. Available from: https://omim.org/entry/600694?search=GP130&highlight=gp130spa
dc.relation.referencesKishimoto T, Akira S, Narazaki M, Taga T. Interleukin-6 family of cytokines and gp130. Blood [Internet]. 1995;86(4):1243–54. Available from: http://dx.doi.org/10.1182/blood.V86.4.1243.bloodjournal8641243spa
dc.relation.referencesKishimoto T, Taga T, Akira S. Cytokine signal transduction. Cell [Internet]. 1994;76(1):253–62. Available from: doi:10.1016/0092-8674(94)90333-6spa
dc.relation.referencesSzalai C, Tóth S, Falus A. Exon-intron organization of the human gp130 gene. Gene [Internet]. 2000;243(1–2):161–6. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0378111999005363?via%3Dih ubspa
dc.relation.referencesWolf J, Waetzig GH, Chalaris A, Reinheimer TM, Wege H, Rose-John S, et al. Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine- tune the Blockade of Interleukin-6 Trans-signaling *. J Biol Chem [Internet]. 2016;291(31):16186–96. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965567/spa
dc.relation.referencesKraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, et al. Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance. Cell Metab [Internet]. 2015;21(3):403–16. Available from: http://dx.doi.org/10.1016/j.cmet.2015.02.006spa
dc.relation.referencesPlested JS, Coull PA, Gidney MAJ. Cap 15. ELISA. In: Haemophilus influenzae Protocols Methods in Molecular MedicineTM.spa
dc.relation.referencesThermo Fisher Scientific. Human TIMP-2 ELISA Kit [Internet]. Available from: https://www.thermofisher.com/elisa/product/TIMP2-Human-ELISA-Kit/EHTIMP2spa
dc.relation.referencesMillipore. Human sgp130 ELISA KIT. Available from: https://www.sigmaaldrich.com/catalog/product/sigma/rab0315?lang=en&region=COspa
dc.relation.referencesNakatsukasa H, Masuyama H, Akahori Y, Inoue S, Masumoto A, Hiramatsu Y. Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord. Acta Obs Gynecol Scand [Internet]. 2008;87(12):1322–8. Available from: https://obgyn.onlinelibrary.wiley.com/doi/full/10.1080/00016340802468332spa
dc.relation.referencesRodríguez Ordóñez F, Pérez Riaño D, León Martín A, Mosquera Zárate A, Rojas Ávila A, Forero Villamil CA, et al. Correlación entre características físicas neonatales y maternas con el recuento total de células nucleadas y de células CD34+ por microlitro en sangre de cordón umbilical. Rev Med [Internet]. 2015;23(2):71. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121- 52562015000200008spa
dc.relation.referencesChandra T, Afreen S, Kumar A, Singh U, Gupta A. Does umbilical cord blood-derived CD34 + cell concentration depend on the weight and sex of a full-term infant? J Pediatr Hematol Oncol [Internet]. 2012;34(3):184–7. Available from: https://pubmed.ncbi.nlm.nih.gov/22441709/#:~:text=A number of factors such,normal vaginal and cesarean deliveries.spa
dc.relation.referencesHoefer J, Dal-Pont C, Jochberger S, Fantin R, Schennach H. The ‘rejuvenating factor’ TIMP-2 is detectable in human blood components for transfusion. Vox Sang [Internet]. 2020;2:1–7. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/vox.13023spa
dc.relation.referencesWang XX, Tan MS, Yu JT, Tan L. Matrix metalloproteinases and their multiple roles in Alzheimer’s disease. Biomed Res Int [Internet]. 2014;2014:1–8. Available from: https://www.hindawi.com/journals/bmri/2014/908636/spa
dc.relation.referencesDe Stefano ME, Herrero MT. The multifaceted role of metalloproteinases in physiological and pathological conditions in embryonic and adult brains. Prog Neurobiol [Internet]. 2017;155:36–56. Available from: http://dx.doi.org/10.1016/j.pneurobio.2016.08.002spa
dc.relation.referencesCabral-Pacheco GA, Garza-Veloz I, Rosa CCD La, Ramirez-Acuña JM, Perez- Romero BA, Guerrero-Rodriguez JF, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci [Internet]. 2020;21(24):1–53. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767220/spa
dc.relation.referencesVallejo J. Fisiopatología de la ruptura prematura de membranas y marcadores. Obstetricia [Internet]. 2013;(607):543–9. Available from: https://www.medigraphic.com/pdfs/revmedcoscen/rmc-2013/rmc133zb.pdfspa
dc.relation.referencesLee S, Buhimschi CS, Bahtiyar O, Thung SF, Funai EF, Ali UA, et al. Membranes and Preterm Premature Rupture of the Birth, Intra-Amniotic Inflammation, Preterm- Signaling System in Trans IL-6. J Immunol [Internet]. 2011;186(5):3226–3236. Available from: http://www.jimmunol.org/content/186/5/3226spa
dc.relation.referencesJanowska-Wieczorek A, Marquez LA, Dobrowsky A, Ratajczak MZ, Cabuhat ML. Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokines. Exp Hematol [Internet]. 2000;28(11):1274– 85. Available from: https://pubmed.ncbi.nlm.nih.gov/11063876/spa
dc.relation.referencesGranados Cuao Jersson Luis. Expresión del receptor tipo toll 4 en células deciduales estromales humanas asociadas a complicaciones del embarazo [Internet]. Vol. 53, Journal of Chemical Information and Modeling. J Chem Inf Model [Internet]. 2019;53(9):1689–99. Available from: https://repositorio.udes.edu.co/bitstream/001/651/1/Expresión del receptor tipo toll 4 en células deciduales estromales humanas asociadas a complicaciones del embarazo.pdfspa
dc.relation.referencesSommer J, Garbers C, Wolf J, Trad A, Moll JM, Sack M, et al. Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10. J Biol Chem [Internet]. 2014;289(32):22140–50. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139227/spa
dc.relation.referencesDonaldson C, Armitage WJ, Laundy V, Barron C, Buchanan R, Webster J, et al. Impact of obstetric factors on cord blood donation for transplantation. Br J Haematol [Internet]. 1999;106(1):128–32. Available from: https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365- 2141.1999.01507.x?sid=nlm%3Apubmedspa
dc.relation.referencesJones J, Stevens CE, Rubinstein P, Robertazzi RR, Kerr A, Cabbad MF. Obstetric predictors of placental / umbilical cord blood volume for transplantation. Gen Obstet Gynecol Obstet [Internet]. 2000;188(2):503–9. Available from: https://www.ajog.org/article/S0002-9378(02)71349-5/fulltextspa
dc.relation.referencesZhang L, Zhang Z, Gao Y, Zhang L, Jia L, Wang P, et al. Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia. Hypertens Pregnancy [Internet]. 2013;32(3):270–80. Available from: https://www.tandfonline.com/doi/abs/10.3109/10641955.2013.798332?journalCode=ih ip20spa
dc.relation.referencesNissi R, Talvensaari-Mattila A, Kotila V, Niinimäki M, Järvelä I, Turpeenniemi- Hujanen T. Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are associated with spontaneous early pregnancy failure. Reprod Biol Endocrinol [Internet]. 2013;11(1):1–6. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566964/spa
dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembProteínas Neuromoduladoras
dc.subject.lembNeonatos
dc.subject.lembPlasma
dc.subject.lembAngiogénesis
dc.subject.proposalTIMP-2spa
dc.subject.proposalsgp130spa
dc.subject.proposalHipocampospa
dc.subject.proposalPlasma de sangre de cordón umbilicalspa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_14cbspa


Ficheros en el ítem

Thumbnail
Nombre:
FORMATO DERECHOS DE AUTOR TGK ...
Tamaño:
291.1Kb
Formato:
PDF
Ver/
Thumbnail
Nombre:
Liseth Daniela Holguin, Katherine ...
Tamaño:
1.136Mb
Formato:
PDF
Ver/
Thumbnail
Nombre:
Formato decanatura......pdf
Tamaño:
77.27Kb
Formato:
PDF
Ver/
Thumbnail
Nombre:
Liseth Daniela Holguin, Katherine ...
Tamaño:
4Mb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2021
Excepto si se señala otra cosa, la licencia del ítem se describe como Derechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2021