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Evaluación de los niveles de la proteína Dickkopf- 1 (Dkk-1) y su asociación con índices de actividad clínica reumática en pacientes con Artritis Reumatoide temprana

dc.contributor.advisorRomero Sánchez, María Consuelo
dc.contributor.advisorChila Moreno, Leidy Lorena
dc.contributor.advisorNavarrete, Janeth
dc.contributor.authorArias Arias, Angela Miyared
dc.date.accessioned2021-12-02T21:11:52Z
dc.date.available2021-12-02T21:11:52Z
dc.date.issued2018-05-31
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/3762
dc.description.abstractLa artritis reumatoide (AR) es una enfermedad de naturaleza autoinmune sistémica, se caracteriza por un estado de inflamación crónico, discapacidad progresiva, daño osteoarticular y consecuencias socioeconómicas de gran impacto en la calidad de vida del paciente. La determinación de la AR en etapas tempranas de la enfermedad puede predecir desenlaces del trastorno y así disminuir daños irreversibles. La EULAR/ACR establecieron en el año 2010 una serie de criterios clínicos clasificatorios y pruebas de laboratorio que incluyen el Factor Reumatoide (FR) y los anticuerpos anti-proteínas citrulinadas (anti-CCP), los cuales están asociados a la actividad de la enfermedad y al pronóstico de la misma. La identificación de nuevos biomarcadores que puedan asociarse a manifestaciones en estadios tempranos de le enfermedad ha cobrado gran interés, ya que hay pacientes que presentan niveles muy bajos o indetectables de FR y anti-CCP aun así presentando un elevado daño articular, dificultando el diagnóstico y las posibles opciones terapéuticas. La proteína Dickkopf-1 (DKK-1) es un regulador de la masa ósea y remodelación articular, se ha evidenciado su aumento a nivel sérico en presencia de resorción ósea, asociándose a un elevado valor predictivo en el desarrollo y severidad de la enfermedad. En el presente estudio se pretende establecer los niveles de la proteína DKK-1 en pacientes con diagnóstico de AR temprana y su asociación con índices de actividad clínica reumática, con el fin de determinar las condiciones que asocian la presencia de la DKK-1 y sus posibles capacidades de pronóstico durante el curso de la enfermedad.spa
dc.description.tableofcontentsRESUMEN 8 INTRODUCCIÓN 10 1. OBJETIVOS 12 5.1 OBJETIVO GENERAL 12 5.2 OBJETIVOS ESPECÍFICOS 12 ANTECEDENTES 13 2. MARCO TEÓRICO 19 6.1 ARTRITIS REUMATOIDE 19 6.2 BIOMARCADORES ASOCIADOS A ENFERMEDAD 20 6.3 MANIFESTACIONES CLÍNICAS 25 6.3.1 EROSIONES OSEAS EN ARTRITIS REUMATOIDE 25 6.4 VÍA Wnt 28 6.4.1 LA VÍA CANÓNICA 29 6.4.2 VÍA NO CANÓNICA 30 6.5 PROTEÍNA DICKKOPF-1 (DKK-1 31 6.6 RELACIÓN ENTRE NIVELES DE DKK1 Y DESENLACES EN AR 32 3. METODOLOGÍA 34 7.1 . TIPO DE INVESTIGACIÓN 34 7.2 POBLACIÓN 34 7.3 MUESTRA 34 7.4 SELECCIÓN DE LA MUESTRA 34 7.5 CRITERIOS DE INCLUSIÓN 35 7.6 CRITERIOS DE EXCLUSIÓN 35 7.7 TÉCNICAS Y PROCEDIMIENTOS 35 7.8 ASPECTOS ÉTICOS 37 4. RESULTADOS 38 5. DISCUSIÓN 57 6. CONCLUSIONES 59 7. REFERENCIAS 65 ÍNDICE DE FIGURASspa
dc.format.extent73p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsUniversidad Colegio Mayor de Cundinamarca, 2018spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleEvaluación de los niveles de la proteína Dickkopf- 1 (Dkk-1) y su asociación con índices de actividad clínica reumática en pacientes con Artritis Reumatoide tempranaspa
dc.typeTrabajo de grado - Pregradospa
dc.contributor.corporatenameUniversidad Colegio Mayor de Cundinamarcaspa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.identifier.barcode58425
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.relation.referencesPischon N, Pischon T, Kröger J, Gülmez E, Kleber B-M, Bernimoulin J-P, et al. Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol. 2008;79(6):979–86.spa
dc.relation.referencesÄyräväinen L, Leirisalo-Repo M, Kuuliala A, Ahola K, Koivuniemi R, Meurman JH, et al. Periodontitis in early and chronic rheumatoid arthritis: a prospective follow-up study in Finnish population. BMJ Open [Internet]. 2017;7(1):e011916spa
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dc.relation.referencesBello-Gualtero J, etal. Periodontal disease in subjects with genetic risk to develop arthritis and early rheumatoid arthritis: a cross sectional study. J periodontol 2016;87:346-456.spa
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dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembEnfermedad
dc.subject.lembNaturaleza autoinmune
dc.subject.lembEULAR/ACR
dc.subject.proposalArtritis reumatoidespa
dc.subject.proposalProteína DKK-1spa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_14cbspa


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Universidad Colegio Mayor de Cundinamarca, 2018
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