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Perfil metabolómico diferencial en suero de pacientes con Esclerosis Sistémica y Síndrome de Sjögren

dc.contributor.advisorAcosta Ampudia, Yeny
dc.contributor.advisorNavarrete Ospina, Jeannette
dc.contributor.authorMoreno Rubiano, Laura Alejandra
dc.contributor.authorSierra Hernández, Olga Lucía
dc.date.accessioned2022-09-27T19:58:37Z
dc.date.available2022-09-27T19:58:37Z
dc.date.issued2022
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/5673
dc.description.abstractLas enfermedades autoinmunes son patologías que representan un problema de salud pública por el deterioro de la calidad de vida de las personas que las padecen. Estas enfermedades se definen como la respuesta anormal del sistema inmunológico a moléculas propias o autoantígenos específicos llevando a daño en tejidos; su desarrollo es multifactorial, por lo que en su estudio es imprescindible tener en cuenta los factores ambientales, genéticos, entre otros. La metabolómica es la ciencia ómica que estudia metabolitos, por medio de esta se pueden estudiar eventos biológicos y así determinar alteraciones relevantes en procesos de enfermedades. Es así que el objetivo de esta investigación es abordar desde la perspectiva de la metabolómica los cambios que se pueden encontrar en perfiles metabolómicos entre pacientes con Esclerosis Sistémica y Síndrome de Sjögren. De esta forma se encuentra que hay metabolitos a destacar en estas enfermedades como los ácidos grasos y metabolitos derivados de aminoácidos entre ellos el triptófano los cuales pueden intervenir en su patología. Este estudio proporciona información relevante para futuras investigaciones, lo que supondría un apoyo en la búsqueda futura de nuevos metabolitos que puedan contribuir en el desarrollo de las enfermedades tratadas en este trabajospa
dc.description.tableofcontentsTabla de contenido Resumen 8 Introducción 9 1. Antecedentes 11 2. Marco Teórico 13 2.1 Autoinmunidad y ecología autoinmune 13 2.2 Metabolómica 18 2.2.1 Técnicas utilizadas en metabolómica 19 2.2.2 Análisis bioestadístico de datos 22 2.3 Esclerosis Sistémica y Síndrome de Sjogren 24 2.3.1 Esclerosis Sistémica 24 2.3.2 Síndrome de Sjogren 26 3. Diseño Metodológico 28 3.1. Universo, población, muestra 28 3.2. Hipótesis, variables, indicadores 28 3.3. Operacionalización de las variables 29 3.4. Técnicas y procedimientos 30 4. Resultados 31 4.1 Metabolitos encontrados en Esclerosis Sistémica y Síndrome de Sjogren 32 4.2 Rutas metabólicas alteradas en Esclerosis Sistémica y Síndrome de Sjogren 34 5. Discusión 38 5.1 Metabolómica de Esclerosis Sistémica 38 5.2 Metabolomica de Síndrome de Sjogren 40 5.3 Metabolómica de Esclerosis Sistémica y Síndrome de Sjogren 43 6. Conclusiones 43 7. Perspectivas 44 8. Referencias Bibliográficas 45 9. Anexos 54eng
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dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2022spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titlePerfil metabolómico diferencial en suero de pacientes con Esclerosis Sistémica y Síndrome de Sjögreneng
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembSuero
dc.subject.lembMetabolito
dc.subject.lembEcología autoinmune
dc.subject.lembAutoinmunidad
dc.subject.proposalMetabolómicaspa
dc.subject.proposalEsclerosis Sistémicaspa
dc.subject.proposalSíndrome de Sjögrenspa
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