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Evaluación de los mecanismos biológicos que explican el compromiso intestinal en pacientes con Espondiloartritis: Una revisión de la literatura

dc.contributor.advisorDe Avila Quiroga, Juliette
dc.contributor.advisorRamos Casallas, Manuel Alejandro
dc.contributor.authorBolivar Fonseca, Evelin Estefany
dc.date.accessioned2024-05-20T17:45:42Z
dc.date.available2024-05-20T17:45:42Z
dc.date.issued2023
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/6875
dc.description.abstractLa espondiloartritis (EspA) es un grupo de enfermedades que comparten manifestaciones clínicas como inflamación en articulaciones y/o vertebras (1), cuyo origen es desconocido. A pesar de ello, hay diferentes postulados que explican la posible etiopatogénesis, como por ejemplo el péptido artritogénico (2), el plegamiento anómalo de las cadenas pesadas del HLA-B27, entre otros (3). A esta discusión recientemente se suma la detección de inflamación intestinal subclínica y síntomas relacionados a la misma, planteando que la disbiosis intestinal estaría implicada en la génesis de la enfermedad. Por ende, mediante la búsqueda controlada por tesauros y terminología determinada, se realizó una exploración en las bases de datos Embase, PubMed, Scopus y Google Scholar; de los cuales se recuperaron 1556 artículos, de los que se seleccionaron 8 publicaciones de acuerdo con los criterios de elegibilidad como idioma, tipo de estudio, población estudiada, etcétera. Los estudios seleccionados destacan la disbiosis como factor fundamental en la génesis de la EspA, ya que esta genera cambios en los metabolitos producidos por los microorganismos del intestino, los cuales pueden desatar una respuesta inflamatoria al existir un mimetismo por el HLA-B27, de acuerdo a la activación de linfocitos T del epitelio del colon, esta exacerbación del sistema inmune se puede translocar a diferentes zonas del cuerpo durante la migración de las células mencionadas; por otra parte se indaga el impacto de algunas terapias sobre las comunidades microbianas del intestino, ya que pueden perpetuar la disbiosis en los pacientes con EspA o restablecer de manera parcial el equilibrio del microbiota intestinal.spa
dc.description.tableofcontentsTABLA DE CONTENIDO 1. RESUMEN 2. INTRODUCCIÓN 3. DESCRIPCIÓN DEL PROYECTO. 2.1 Justificación. 2.2 Pregunta de investigación e hipótesis 4. OBJETIVOS. 4.1. Objetivo general 4.2. Objetivos específicos 5. MARCO TEORICO. 5.1 Espondiloartritis 5.2 Situación epidemiológica en Colombia 5.3 Compromiso intestinal en pacientes con EspA 5.4 Respuesta inmune en mucosas 5.5 Respuesta inmune en mucosa intestinal en EspA 5.6 Disbiosis 5.7 Tratamiento en pacientes con EspA 6. METODOLOGÍA. 6.1.1. Criterios de elegibilidad 6.1.1.1. Criterios de inclusión 6.1.1.2. Criterios de exclusión 6.1.2. Fuentes de información 6.1.3. Estrategia de búsqueda 6.1.4. Selección de estudios 6.1.5. Evaluación y análisis de datos 7. RESULTADOS. 8. DISCUSIÓN 9. CONCLUSION 10. REFERENCIAS BIBLIOGRÁFICAS. 11. ANEXOSspa
dc.format.extent70p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.titleEvaluación de los mecanismos biológicos que explican el compromiso intestinal en pacientes con Espondiloartritis: Una revisión de la literaturaspa
dc.typeTrabajo de grado - Pregradospa
dc.contributor.corporatenameUniversidad Colegio Mayor de Cundinamarcaspa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.Cspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.subject.proposalEspondiloartritisspa
dc.subject.proposalInflamación intestinal subclínicaspa
dc.subject.proposalDisbiosisspa
dc.subject.proposalHLA-B27spa
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