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Influencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresión

dc.contributor.advisorCamacho Kurmen, Judith Elena
dc.contributor.authorOrtegón Orduña, Juanita
dc.contributor.authorZuluaga Echeverri, Luz Yerly
dc.date.accessioned2024-05-23T17:29:55Z
dc.date.available2024-05-23T17:29:55Z
dc.date.issued2022-04
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/6912
dc.description.abstractLa depresión es un trastorno caracterizado por la presencia de tristeza, pérdida de interés, sentimientos de culpa; se puede clasificar como leve, moderada o grave. El presente trabajo se centra en la influencia de los inhibidores selectivos de la recaptación de serotonina (ISRS) en la microbiota intestinal de las personas con depresión. Se basa en el eje intestino-cerebro que consiste en una red de comunicación que monitorea e integra las funciones intestinales y las vincula a los centros cognitivos y emocionales del cerebro. Esta investigación se lleva a cabo por una revisión bibliográfica y un análisis bibliométrico, donde se explica el eje, se analiza el impacto en la microbiota con el uso de antidepresivos, se describe el efecto de estos en pacientes con depresión y se indagan los tratamientos adicionales que pueden ser utilizados. Los ISRS son medicamentos de primera línea, estos inhiben los transportadores de serotonina aumentando los niveles de 5-hidroxitriptamina, la concentración prolongada de estos en la luz intestinal afectan la microbiota generando disbiosis, la cual se puede prevenir con el uso de probióticos, prebióticos, psicobióticos o dieta. Como conclusión los ISRS poseen acción antimicrobiana, el tratamiento más prometedor es el uso de probióticos por el gran beneficio que conlleva en el intestino. A nivel nacional pese al desarrollo de una Política Pública de Salud Mental no se cuenta con la cobertura adecuada se dificulta el acceso a los servicios y tratamientos incompletos; por lo que se sugiere seguir investigando sobre el tema y en planes de prevención.spa
dc.description.tableofcontentsTABLA DE CONTENIDO RESUMEN 6 INTRODUCCIÓN 8 1. ANTECEDENTES 10 2. MARCO REFERENCIAL 16 3. DISEÑO METODOLÓGICO 27 3.1. Universo, población y muestra 27 3.2. Hipótesis, variables, indicadores 27 3.3. Técnicas, procedimientos 28 4. RESULTADOS Y DISCUSIÓN 29 5. CONCLUSIONES 36 6. REFERENCIAS BIBLIOGRÁFICAS 37 7. ANEXOS 51spa
dc.format.extent105p.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherUniversidad Colegio Mayor de Cundinamarcaspa
dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2024spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.titleInfluencia de los inhibidores selectivos de recaptación de serotonina en la microbiota intestinal de personas con depresiónspa
dc.typeTrabajo de grado - Pregradospa
dc.contributor.corporatenameUniversidad Colegio Mayor de Cundinamarcaspa
dc.description.degreelevelPregradospa
dc.description.degreenameBacteriólogo(a) y Laboratorista Clínicospa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotá D.C.spa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.subject.proposalDepresiónspa
dc.subject.proposalMicrobiota intestinalspa
dc.subject.proposalInhibidores Selectivos de la Recaptación de Serotonina (ISRS)spa
dc.subject.proposalDisbiosis intestinalspa
dc.subject.proposalTratamientospa
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