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Microbiota intestinal en pacientes con enfermedades neurodegenerativas: revisión bibliográfica

dc.contributor.advisorCubillos Abello, Karen Andrea
dc.contributor.authorPrieto Cerquera, Bleidy Yelissa
dc.contributor.authorSalazar Quintero, Angie Daniela
dc.date.accessioned2022-10-03T19:38:14Z
dc.date.available2022-10-03T19:38:14Z
dc.date.issued2022
dc.identifier.urihttps://repositorio.unicolmayor.edu.co/handle/unicolmayor/5675
dc.description.abstractLa microbiota intestinal es la comunidad de microorganismos vivos residentes en el tubo digestivo, compuesta por bacterias, virus y hongos, que se adquieren después del nacimiento y que cumplen varias funciones importantes.La microbiota intestinal está determinada por factores como la edad, la alimentación, la genética, el ambiente, entre otros. Se ha descubierto que existe una relación entre la disbiosis o alteración de la composición de la microbiota y el desarrollo de enfermedades autoinmunes, inflamatorias y enfermedades neurodegenerativas como la enfermedad de Parkinson (EP) y el Alzheimer (EA). Estudios evidencian que el intestino y el sistema nervioso central (SNC) se comunican entre sí. La secuenciación del gen de ARN ribosómico 16S (ARNr) pone en evidencia que la microbiota intestinal bacteriana se encuentra alterada en algunas enfermedades neurodegenerativas y comprueba que la diversidad de la microbiota intestinal disminuye sobre todo en edades adultas. Esto, explica que el envejecimiento puede aumentar la inflamación intestinal y cambiar los taxones bacterianos; así se incrementan las bacterias proinflamatorias y disminuyen las bacterias antiinflamatorias, desencadenando inflamación sistémica del SNC, lo que resulta en una neurodegeneración. En esta monografía se ofrece una revisión bibliográfica, donde se busca comparar la microbiota intestinal en personas sanas y en personas con enfermedades neurodegenerativas y relacionar la disbiosis intestinal con el desarrollo de estas enfermedades. Así mismo, se pretende contribuir en futuras investigaciones sobre el uso de estrategias que permitan mejorar el proceso de diagnóstico y pronostico temprano en el desarrollo de enfermedades crónicas del sistema nervioso y asi llegar a evitar la manifestacion de sintomasneurologicos que bajan la calidad de vida humana.spa
dc.description.tableofcontentsTABLA DE CONTENIDO Resumen Introducción Objetivos 1. Marco Teórico 1.1 Antecedentes 1.2 Enfermedades Neurodegenerativas 1.2.1 Enfermedad de Alzheimer 1.2.1.1 Características Clínicas 1.2.1.2 Diagnóstico 1.2.2 Enfermedad de Parkinson 1.2.2.1 Características Clínicas 1.2.2.2 Diagnóstico 1.3 Microbiota Intestinal 1.3.1 Funciones de la Microbiota 1.3.2 Métodos para el estudio de la microbiota intestinal 2. Diseño metodológico 2.1 Tipo de investigación 2.2 Alcance de la investigación 2.3 Población objeto de muestra 2.4 Muestra del análisis 3. Resultados 3.1 Fuentes de investigación 3.2 Resultados de la revisión bibliográfica 3.2.1 Ecología intestinal de la Enfermedad de Alzheimer 3.2.2 Ecología intestinal de la Enfermedad de Parkinson 3.2.3 Eje Microbiota-Intestino-Cerebro 3.2.4 Eje Microbiota-Intestino-Cerebro en enfermedad y la inmunidad 3.2.5 Eje Microbiota-Intestino-Cerebro en enfermedad de Alzheimer 3.2.6 Eje Microbiota-Intestino-Cerebro en enfermedad de Parkinson 4. Discusión 5. Conclusioneeng
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dc.format.mimetypeapplication/pdfspa
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dc.rightsDerechos Reservados - Universidad Colegio Mayor de Cundinamarca, 2022spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.titleMicrobiota intestinal en pacientes con enfermedades neurodegenerativas: revisión bibliográficaspa
dc.typeTrabajo de grado - Pregradospa
dc.description.degreelevelPregradospa
dc.description.degreenameAbogado(a)spa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.placeBogotaspa
dc.publisher.programBacteriología y Laboratorio Clínicospa
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dc.rights.accessrightsinfo:eu-repo/semantics/closedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)spa
dc.subject.lembParkinson
dc.subject.lembAlzheimer
dc.subject.proposalMicrobiota intestinalspa
dc.subject.proposalEnfermedades neurodegenerativasspa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TPspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.coarhttp://purl.org/coar/access_right/c_14cbspa


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